Evaluation of Safety and Efficacy of an Inactivated Marker Vaccine against Bovine alphaherpesvirus 1 (BoHV-1) in Water Buffalo (Bubalus bubalis)

Evaluation of Safety and Efficacy of an Inactivated Marker Vaccine against Bovine alphaherpesvirus 1 (BoHV-1) in Water Buffalo (Bubalus bubalis)

Blog Article

Recent studies have explored the seropositivity of Bovine alphaherpesvirus 1 (BoHV-1) in water buffaloes, suggesting the urgency for developing strategies to eradicate the virus involving both cattle and water buffaloes.However, in Wooden Toy Europe, the glycoprotein E (gE) deleted marker vaccines against BoHV-1 are commercially available only for the cattle industry.This study, for the first time, evaluated the safety and efficacy of a commercial inactivated gE-deleted marker vaccine in water buffalo.

Five animals devoid of BoHV-1-neutralizing antibodies were vaccinated via intramuscular route.Five additional animals served as an unvaccinated control group.Sixty days after the first immunization, all animals were experimentally infected with a virulent BoHV-1via intranasal route.

A detectable BoHV-1-humoral immune response was observed in the vaccinated group on post-vaccination day 30, whereas the antibodies appeared on post-challenge day 10 in the control group.Moreover, the vaccinated animals neither show viral shedding nor clinical signs compared to the control upon challenge.However, post-challenge, the BoHV-1-specific humoral and cell-mediated immune responses were significantly more increased in vaccinated animals than the control animals.

Overall, the present study provides evidence of both the safety and efficacy of an inactivated gE-deleted marker vaccine against Grinders BoHV-1 in water buffaloes.